The treatment for erectile dysfunction (ED) was revolutionized with the development of phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil (Cialis®; Eli Lilly and Company, Indianapolis, IN, USA) is the newest and most versatile PDE5 inhibitor in the clinical armamentarium for the treatment of ED. Its most unique characteristic is its long half-life of 17.5 hours, which lends itself to a longer therapeutic window with on-demand dosing and effective steady-state plasma concentrations with once-daily dosing. Clinical trials have proven its safety and efficacy with both dosing strategies for all severities and etiologies of ED, including difficult-to-treat ED. This thorough review will discuss ED, the physiology of penile erection and the role of PDE5, and all aspects of tadalafil, from its development, through its pharmacology, to its latest clinical studies and indications.
Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis.
Tadalafil works by preventing the action of a chemical in your body, called phosphodiesterase type-5. This helps to relax (widen) blood vessels and improves the flow of blood to the penis following sexual stimulation. This helps to maintain an erection.
Tadalafil is available on prescription, but it is only prescribed on the NHS for men with erectile dysfunction resulting from certain medical conditions. If you are given a private (non-NHS) prescription, you will be asked to pay for the tablets.
Another brand of tadalafil tablets called Cialis is used to treat a completely different condition called pulmonary arterial hypertension - see the separate medicine leaflet called Tadalafil for pulmonary hypertension if you have been prescribed this brand of tadalafil tablets.
Primary pulmonary hypertension is a rare condition where there is too high a blood pressure in the blood vessels that supply your lungs from your heart.
Cialis Soft belongs to the generic drugs of Brand Cialis 20mg and has improved formula, which helps to absorb the medication quicker than other similar drugs. Such a rapid effect is ensured because of the pill consistency, which gets directly into blood and not into the stomach like other medications. The active component is presented by Tadalafil, which is included in all pills of brand and generic Cialis.
Tadalafil 20mg soft tablets is available in a pill form, which has nice flavor and need to be taken by putting it under the tongue and sucking. The mechanism of action of the drug is the same as in other similar drugs, which are designed to strengthen the sexual function of men. It increases the blood flow to the genital area and cause the erection. After the intake of the Tadalafil pill, the effect occurs in 15-30 minutes and lasts up to 36 hours. You can take soft pills with fatty food and alcohol, but not with grapefruit juice, because it can reduce or slow down the efficiency of the drug.